Opportunities and challenges to the use of neutralizing monoclonal antibody therapies for COVID-19
نویسندگان
چکیده
The coronavirus disease 2019 (COVID-19) pandemic has resulted in a substantial global public healthcare crisis, leading to the urgent need for effective therapeutic strategies. Neutralizing antibodies (nAbs) are potential treatment COVID-19. This article provides brief overview of targets and development nAbs against COVID-19, it examines efficacy as part both outpatient inpatient treatments based on emerging clinical trial data. Assessment several promising candidates trials highlights be an treat COVID-19 settings. Nevertheless, hospitalized patients varies. In addition, this review identifies challenges ending pandemic, including concerns over use. Resistant variants significantly threaten availability nAb-based therapeutics. also discusses other approaches that may improve benefit neutralizing mAbs.
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ژورنال
عنوان ژورنال: BioScience Trends
سال: 2021
ISSN: ['1881-7815', '1881-7823']
DOI: https://doi.org/10.5582/bst.2021.01227